Characterization of CTL Clones Specific for Single Antigen, H60 Minor Histocompatibility Antigen
نویسندگان
چکیده
منابع مشابه
Characterization of CTL Clones Specific for Single Antigen, H60 Minor Histocompatibility Antigen
BACKGROUND Disparities of Minor H antigens can induce graft rejection after MHC-matched transplantation. H60 has been characterized as a dominant antigen expressed on hematopoietic cells and considered to be an ideal model antigen for study on graft-versus-leukemia effect. METHODS Splenocytes from C57BL/6 mice immunized with H60 congenic splenocytes were used for establishment of H60-specific...
متن کاملSelection of Thymocytes Expressing Transgenic TCR Specific for a Minor Histocompatibility Antigen, H60
Minor histocompatibility antigens are MHC-bound peptides and contribute to the generation of allo-responses after allogeneic transplantation. H60 is a dominant minor H antigen that induces a strong CD8 T-cell response in MHC-matched allogeneic transplantation settings. Here, we report establishment of a TCR transgenic mouse line named J15, wherein T cells express TCRs specific for H60 in comple...
متن کاملAltered distribution of H60 minor H antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3-/- mouse recipients.
Chemokine-chemokine receptor interactions and the subsequent recruitment of T lymphocytes to the graft are believed to be among the initial events in the development of acute and chronic rejection of heart transplants. We sought to determine the role of chemokine receptor Cxcr3 on the development of acute and chronic rejection in a multiple minor Ag mismatched mouse heart transplant model. The ...
متن کاملCD8(+) minor histocompatibility antigen-specific cytotoxic T lymphocyte clones eliminate human acute myeloid leukemia stem cells.
Effective immunotherapy for human leukemia based on infusions of T lymphocytes requires the identification of effector T cells that target the leukemic stem cell. The transplantation of human acute myeloid leukemia into nonobese diabetic/severe combined immune deficient (SCID) mice has identified a rare leukemic progenitor termed the SCID leukemia-initiating cell, which is present in low freque...
متن کاملCord blood comprises antigen-experienced T cells specific for maternal minor histocompatibility antigen HA-1.
Umbilical cord blood transplantation is applied as treatment for mainly pediatric patients with hematologic malignancies. The clinical results show a relatively low incidence of graft-versus-host disease and leukemia relapse. Since maternal cells traffic into the fetus during pregnancy, we questioned whether cord blood has the potential to generate cytotoxic T cells specific for the hematopoiet...
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ژورنال
عنوان ژورنال: Immune Network
سال: 2011
ISSN: 1598-2629,2092-6685
DOI: 10.4110/in.2011.11.2.100